How may the church claim that Christ is the only Savior in a world in which tolerance and relativism are prized and societies are increasingly religiously plural? How does the Spirit empower believers and communities in their daily life and work as they face formidable cultural and ideological challenges? Such questions these essays answer. Half originated at "Proclaiming Christ in the Face of Challenges," the 2018 Scholars¿ Consultation of Empowered21, a global network of Spirit-empowered churches and communities. This Consultation¿s location in Johannesburg accounts for eight essays¿ focusing on distinctively African concerns; another four center on Asia and the Global South and three on Europe. Others address Western concerns of modernism, postmodernism, secularism, and pluralism, while several probe biblical and historical-theological foundations of Christian faith and its Spirit-empowered proclamation. Readers will benefit from exploring the universality of the Christian gospel from its fi rst proclamation and its proven adaptability to the cultural pluralism that is today¿s global reality, a flexibility that is faithful to God¿s revelation and effective in imparting divine life where proclaimed and believed.