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Progress in Cell Cycle Control Research

Editat de K.L. Chen
en Limba Engleză Hardback – 31 oct 2008
A cell cycle is an ordered and highly controlled set of events that leads to cell growth and proliferation. Cell cycle progression is driven by changes in the substrate specificity and subcellular localisation of cyclin-dependent kinases (Cdks), which in turn are modulated by a collection of cyclins, Cdk-activating and Cdk-inhibiting kinases, and Cdk inhibitors (CDKIs). Regulation of the cell cycle is critical for the normal development of multicellular organisms and dysregulation of cell cycle could lead to cancer, a disease where normal cell growth and behaviour are lost. Cell cycle regulation is tightly controlled by both synthesis and degradation of short-lived proteins, such as cyclins and CDKIs, and degradation of these proteins is mainly mediated by the ubiquitin-dependent proteasome pathway. This book presents the latest research in the field from around the globe.
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Specificații

ISBN-13: 9781604567977
ISBN-10: 160456797X
Pagini: 348
Ilustrații: tables, charts & illus
Dimensiuni: 189 x 262 x 26 mm
Greutate: 0.93 kg
Editura: Nova Science Publishers Inc

Cuprins

Preface; Sizing Up Answers to a Long-Standing Riddle; New Directions for CDKs and HDACs Inhibition in Cancer Therapy; Cell Cycle Control by Proteasome Inhibition: Implications in Cancer Therapies; Cell-Cycle Regulation by Protein Kinase C and Mitogen-Activated Protein Kinase Signaling in Breast Cancer Cells; Fhit and Cancer Initiating Cells; Anti-Tumorigenic Mechanisms Targeting Control of Cell Cycle Beyond the Conserved G1/S and Gs/M Checkpoints - Insights Learned from Studies of Reversine, a Substituted Purine with Regenerative Potential, in Human Prostate Cancer PC-3 Cells; Cell Cycle Control Proteins in Human Breast Cancer; Index.