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Progress in Chemokine Research

Editat de W.P. Linkes
en Limba Engleză Hardback – 5 feb 2007
Chemokines are the cytokines that may activate or chemoattract leukocytes. Each chemokine contains 65 ~ 120 amino acids, with molecular weight of 8-10 kD. Their receptors belong to G-protein-coupled receptors. Inflammatory chemokines are released from a wide variety of cells in response to bacterial infection, viruses and agents that cause physical damage such as silica or the urate crystals that occur in gout. They function mainly as chemoattractants for leukocytes, recruiting monocytes, neutrophils and other effector cells from the blood to sites of infection or damage. They can be released by many different cell types and serve to guide cells involved in innate immunity and also the lymphocytes of the adaptive immune system. The cells that are attracted by chemokines follow a signal of increasing chemokine concentration to the site of infection or tissue injury. Some chemokines also have roles in the development of lymphocytes, migration and angiogenesis (the growth of new blood vessels).Since the entry of HIV into host cells requires chemokine receptors, their antagonists are being developed to treat AIDS. This book presents leading research from around the globe in this field.
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Specificații

ISBN-13: 9781600216411
ISBN-10: 1600216412
Pagini: 217
Ilustrații: tables & charts
Dimensiuni: 188 x 265 x 21 mm
Greutate: 0.71 kg
Editura: Nova Science Publishers Inc

Cuprins

Preface; The Role of Chemokines in the Pathogenesis of Endometriosis; The Role of the Chemokines in Cardiac Disease; Chemokines and Leukocytes: Key Players in Autoimmune Liver Disease; Chemokine Function in Granulomatous Lung Disease; Syndecans as Modulators of Chemokine Function; Chemokines in Acute Pancreatitis; The Role of the Chemokine System in Cancer; Intrathecal Upregulation of Monocyte Chemoattractant Protein-1 and Neurodegeneration in Amyotrophic Lateral Sclerosis; Role of Chemokines in Neurodegeneration; The Function of Interleukin-8 in Prostate Cancer; Serum Levels of Interleukin-16 in Lymphoid Neoplastic Diseases; Chemokine Involvement in Alzheimer's Disease Pathogenesis: Implication for Peripheral Inflammatory Process; Chemokine and the Kidney; Chemokines in Inflammatory Acne; Chemokine Action Involves Self-Perpetuating Transformation in Inflammation and Carcinogenesis; Index.