Proteases, Protease Inhibitors and Protease-Derived Peptides: Importance in Human Pathophysiology and Therapeutics: Agents and Actions Supplements, cartea 42

Overview.- Proteases — Structures, Mechanisms and Inhibitors.- Biochemical Mechanisms for Disrupting the Proteinase-Proteinase Inhibitor Balance in Tissues.- Oxidants, Metalloproteases and Serine Proteases in Inflammation.- Elastase and Oxygen Radicals: Synergistic Interactions.- Neutrophil Elastase Inhibitors: Clinical Potential.- Proteolysis-Induced Pathomechanisms in Acute Inflammation and Related Therapeutic Approaches.- Synthesis and Characterization of Human Neutrophil Elastase Inhibitors Derived from Aromatic Esters of Phenylalkanoic Acids.- In Vivo Evaluation of MDL 201,404YA, A Novel Inhibitor of Human Neutrophil Elastase.- Alpha1-Antitrypsin Augmentation Therapy.- Secretory Leukocyte Protease Inhibitor in Cystic Fibrosis.- Oxidation Resistant Muteins of Antileukoproteinase as Potential Therapeutic Agents.- Proteases and Protease-Derived Peptides in Inflammation.- Factor XII Activation and Inhibition in Inflammation.- The Kinin System in Inflammation.- Role of Bradykinin in Microbial Infection: Enhancement of Septicemia by Microbial Proteases and Kinin.- Kinin Antagonists as Human Therapeutics.- Proteases in Immunoregulation and Cellular Differentiation.- Cytokine Regulation of Endothelial Cell Extracellular Proteolysis.- Different Functional Share of Individual Lysosomal Cathepsins in Normal and Pathological Conditions.- Neuropeptide Processing in Pathophysiology.- Resolution of limp-Free and Timp-Complexed 70kDa Progelatinase from Culture Medium of Rous Sarcoma Virus-Transformed Chicken.- Endotoxin and Eicosanoids.