The present study was aimed to evaluate protective efficacy of a herbal drug Liv.52 against radiation and cadmium induced haematological changes in the Swiss albino mice. The animals treated with gamma radiation and/or cadmium chloride with and without Liv.52 were sacrificed by cervical dislocation at post treatment intervals of 1, 2, 4,7,14 and 28 days. After sacrificing them the blood was collected by cardiac puncture in heparinized tubes for various haematological studies viz. estimation of the value of RBC, WBC, haemoglobin, PCV, MCV, MCH, MCHC, SGOT and SGPT. The Values of RBC, WBC, Hb, PCV and MCV were found to decrease in all the groups as compared to normal group. The values of MCH, MCHC, SGOT, SGPT and monocytes & granulocytes percentage found to increase up to day-14 in non drug treated groups and day-7 in drug treated groups. Thereafter a decrease in the value was observed without reaching to the normal. When the animals were treated with radiation and cadmium chloride simultaneously, synergistic effects were observed. In all drug treated groups recovery started earlier than that in non drug treated groups. The Liv.52 treated animals exhibited less severe damage.