Protein Biosynthesis Interference in Disease
Autor Elena L. Paleyen Limba Engleză Paperback – 13 oct 2020
- Enables biochemists, molecular biologists and disease researchers to advance disease prevention, laboratory testing, and treatment pathways for protein biosynthesis interference related disorders
- Examines the biochemical and molecular basis of protein biosynthesis interference in neurodegenerative disorders, cancer and inflammatory conditions, among other diseases
- Analyzes tryptamine, biogenic amines, and aminoacyl-tRNA synthetases dynamics in protein translation and possible treatment pathways regulating protein biosynthesis
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Specificații
ISBN-13: 9780128234853
ISBN-10: 0128234857
Pagini: 296
Ilustrații: 60 illustrations (40 in full color)
Dimensiuni: 191 x 235 x 19 mm
Greutate: 0.73 kg
Editura: ELSEVIER SCIENCE
ISBN-10: 0128234857
Pagini: 296
Ilustrații: 60 illustrations (40 in full color)
Dimensiuni: 191 x 235 x 19 mm
Greutate: 0.73 kg
Editura: ELSEVIER SCIENCE
Cuprins
1. Introduction2. Tryptamine in the diet, human microbiome, tRNA aminoacylation-protein biosynthesis, host-microbiota metabolic interactions3. Dimethyltryptamine, methyltryptamine, hallucinations and metals4. Psychoactive effects and toxicity of tryptamine, N-methyltryptamine (NMT) and N, N-dimethyltryptamine (DMT): quantification methods5. Tryptamine in renal pathologies and in pregnancy6. Tryptophanyl-tRNA synthetase (TrpRS) inhibition or TrpRS gene (WARS) mutations and deletion result to TrpRS deficiency and pathologies7. Tryptamine in liver diseases and alcohol abuse8. Tryptamine and tyramine in tobacco smoking9. Tryptamine and other biogenic amines in human vaginal samples10. Tryptamine and tryptophan in human fecal samples: diet alters tryptamine levels11. Tryptamine in human noncataractous and cataractous eye lenses12. Tryptamine toxicity in rats, adrenalectomy, toxicity prevention13. Microorganisms: the natural producers of tryptamine in food14. Human gut bacterial sequence associated with Alzheimer’s disease and biogenic amines15. Disease, factors and condition associated with Alzheimer’s disease (AD) and dementia support a concept that AD is a widespread systemic disorder16. Arterial hypertension in comorbidity in dementia and Alzheimer’s disease, tryptamine in metabolic syndrome17. Whole blood viscosity: biogenic amines, dementia and Alzheimer’s disease18. Tryptamine and aminoacyl-tRNAs in sleep-wake and circadian disruptions19. Senile plaques and/or neurofibrillary tangles in brain of non-demented individuals20. Historical perspectives and future research directions21. Tryptamine content and effects in humans and animals22. Link protein half-lives to neurodegeneration: tryptamine treatment effects23. Alzheimer’s disease human gut microbiome associated sequence (ADAS): predictive disease modeling with ADAS: generating ADAS variants from human samples24. Tryptamine and other biogenic amines (BA) as modified and degradable factors25. Tryptamine and TrpRS in cancer and other conditions26. Experimental procedures: tryptophanyl-tRNA synthetase (TrpRS) characterization27. Tryptophanyl-tRNA synthetase (TrpRS) in phosphosignaling28. Tryptophanyl-tRNA synthetase antigenic epitopes and mimotpes29. Interactomes: tryptophanyl-tRNA synthetase forms and other aminoacyl-tRNA synthetases30. Tryptophanyl-tRNA synthetase in cell and organism survival31. Tryptophanyl-tRNA synthetase sharing epitopes32. Tryptamine and Tryptophanyl-tRNA synthetase in microvesicles, multivesicular bodies, and exosomes33. Tryptophanyl-tRNA synthetase and tryptamine in protein kinase and cancer pathways34. Global protein biosynthesis and aminoacyl-tRNA synthetase family