Protein Interaction – The Molecular Basis of Interactomics de V Helms

Protein Interaction – The Molecular Basis of Interactomics

V Helms

This keenly awaited resource for the new field of interactomics systematically covers all types of cellular interactions that proteins engage in, including interactions with other proteins, DNA, RNA, membranes and small molecules.

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Notă biografică

Volkhard Helms has been a full professor for bioinformatics at Saarland University since 2003. He received a Ph.D. for research done at EMBL Heidelberg, did post-doctoral work at UC San Diego, and subsequently was an independent group leader at the Max Planck Institute of Biophysics in Frankfurt. Professor Helms has authored about 200 scientific publications. In 2000, he was named an EMBO Young Investigator. Olga Kalinina is a professor for drug bioinformatics at the Helmholtz Institute for Pharmaceutical Research Saarland since 2019. She received a Ph.D. from the Engelhardt Institute for Molecular Biology of the Russian Academy of Sciences in 2007, did post-doctoral work at EMBL Heidelberg and University of Heidelberg (2007-2011) and subsequently was a group leader at the MPI for informatics in Saarbrücken (2012-2018). Prof. Kalinina has authored over 40 scientific publications.

Cuprins

Protein Structure and Conformational Dynamics Protein-Protein Binding Interfaces Correlated Co-evolving Mutations at Protein-Protein Interfaces Protein-Protein-Docking Identification of Putative Protein Complexes in Protein-Protein Interaction Networks Structures, Composition, and Modelling of Protein Complexes Live-Cell Structural Biology to Solve Molecular Mechanisms: Structural Dynamics in the Exocyst Function Kinetics and Thermodynamics of Protein-Protein Encounter Markov-State Models for Protein-Protein Encounter Transcription Factor-DNA Complexes Chromatin Interactomics Interactions of Proteins with mRNA and ncRNA Interactions Between Proteins and Biological Membranes Interactions of Proteins with Small Molecules Effects of Mutations in Proteins on Their Interactions Not Quite the Same: How Alternative Splicing Affects Protein Interactions Phosphorylation-based Molecular Switches Summary and Outlook