Protein Kinase Inhibitors: From Discovery to Therapeutics
Editat de Md. Imtaiyaz Hassan, Saba Nooren Limba Engleză Paperback – 20 mai 2022
Several potential drugs under different stages of clinical trials are discussed, including their relevance to cancer, diabetes, obesity, cardiovascular, neurological, and auto-immune and inflammatory disease, among other disorders. The book also addresses the challenges and opportunities for future kinase inhibitor development.
- Provides a thorough overview of kinase inhibitor biology and its role in disease progression and modulation
- Examines protein kinase inhibitor drugs in various stages of clinical trials and development
- Offers methods and protocols for protein kinase inhibitor research studies and drug design and development
- Includes chapter contributions from international leaders in the field
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Specificații
ISBN-13: 9780323912877
ISBN-10: 0323912877
Pagini: 830
Ilustrații: 60 illustrations (30 in full color)
Dimensiuni: 191 x 235 x 50 mm
Greutate: 1.7 kg
Editura: ELSEVIER SCIENCE
ISBN-10: 0323912877
Pagini: 830
Ilustrații: 60 illustrations (30 in full color)
Dimensiuni: 191 x 235 x 50 mm
Greutate: 1.7 kg
Editura: ELSEVIER SCIENCE
Cuprins
1. Kinase Inhibitors: An Overview
2. Protein Kinase Inhibitors and cancer targeted therapy
3. Drug discovery for cancer therapy with special reference to inhibitors of protein kinase pathway
4. An insight on PI3K/Akt/mTOR inhibitors in cancer: opportunity and translational perspectives
5. Recent advances in the therapeutic development of ERK inhibitors
6. Emerging small-molecule inhibitors of ATM kinase targeting cancer therapy
7. Targeting Pyruvate Kinase M2 Signaling for Development of Effective Cancer Therapy
8. Serum and glucocorticoid-regulated kinase 1: A potential target for anticancer therapy
9. AKT inhibitors in cancer therapy
10. Aurora kinase: An emerging potential target in therapeutics
11. The Retroactive and Future Potentials of Aurora Kinases in the Treatment of Cancer
12. Targeting the altered tyrosine kinases in colorectal cancer: from inhibitors to drugs
13. PTEN-induced kinase1 (PINK1): Structure, Functions and Role in Human Disease
14. Rho associated protein kinase 1 and 2 (ROCK1&ROCK2) as a potential emerging therapeutic drug target in Alzheimer's disease
15. PDK inhibitors as therapeutic agents: An Overview
16. Polo-like kinases (PLKs): an antimitotic target
17. Src Kinase: An Attractive Therapeutic Target for Prostate Cancer
18. Kinase inhibition in Alzheimer's disease
19. Therapeutic Targeting of Glycogen Synthase Kinase-3: Strategy to address neurodegenerative diseases
20. Microtubule Affinity Regulating Kinase 4: a potential drug target from cancers to neurodegenerative diseases
21. Receptor tyrosine kinase-like orphan receptors ROR1/2: Insights into the mechanism of action, inhibition, and therapeutic potentialIndrakant
22. Therapeutic Potential of Leucine Rich Repeat Kinase 2 (LRRK2) Inhibitors for Parkinson’s Disease Treatment
23. Calcium calmodulin dependent protein kinase as potential drug target
24. Therapeutics of Platelet derived growth factor (PDGF) and signaling in different organs
25. EGFRC797S mutation and fourth generation EGFR tyrosine kinase inhibitors (EGFR-TKIs)
26. Bacterial Histidine Kinases as potential Antibacterial Drug Targets
27. Bacterial Protein Kinases: a target to inhibit the bacterial infections
28. Nanotechnology-based targeted delivery systems for Protein Kinase inhibitors in Cancer therapy
2. Protein Kinase Inhibitors and cancer targeted therapy
3. Drug discovery for cancer therapy with special reference to inhibitors of protein kinase pathway
4. An insight on PI3K/Akt/mTOR inhibitors in cancer: opportunity and translational perspectives
5. Recent advances in the therapeutic development of ERK inhibitors
6. Emerging small-molecule inhibitors of ATM kinase targeting cancer therapy
7. Targeting Pyruvate Kinase M2 Signaling for Development of Effective Cancer Therapy
8. Serum and glucocorticoid-regulated kinase 1: A potential target for anticancer therapy
9. AKT inhibitors in cancer therapy
10. Aurora kinase: An emerging potential target in therapeutics
11. The Retroactive and Future Potentials of Aurora Kinases in the Treatment of Cancer
12. Targeting the altered tyrosine kinases in colorectal cancer: from inhibitors to drugs
13. PTEN-induced kinase1 (PINK1): Structure, Functions and Role in Human Disease
14. Rho associated protein kinase 1 and 2 (ROCK1&ROCK2) as a potential emerging therapeutic drug target in Alzheimer's disease
15. PDK inhibitors as therapeutic agents: An Overview
16. Polo-like kinases (PLKs): an antimitotic target
17. Src Kinase: An Attractive Therapeutic Target for Prostate Cancer
18. Kinase inhibition in Alzheimer's disease
19. Therapeutic Targeting of Glycogen Synthase Kinase-3: Strategy to address neurodegenerative diseases
20. Microtubule Affinity Regulating Kinase 4: a potential drug target from cancers to neurodegenerative diseases
21. Receptor tyrosine kinase-like orphan receptors ROR1/2: Insights into the mechanism of action, inhibition, and therapeutic potentialIndrakant
22. Therapeutic Potential of Leucine Rich Repeat Kinase 2 (LRRK2) Inhibitors for Parkinson’s Disease Treatment
23. Calcium calmodulin dependent protein kinase as potential drug target
24. Therapeutics of Platelet derived growth factor (PDGF) and signaling in different organs
25. EGFRC797S mutation and fourth generation EGFR tyrosine kinase inhibitors (EGFR-TKIs)
26. Bacterial Histidine Kinases as potential Antibacterial Drug Targets
27. Bacterial Protein Kinases: a target to inhibit the bacterial infections
28. Nanotechnology-based targeted delivery systems for Protein Kinase inhibitors in Cancer therapy