Now that the DEA has ruled that spores are legal, the popularity of psilocybin has soared. This 2nd Edition of the Psilocybin Mushroom Handbook provides updated information on navigating the new legal landscape for spores, acquiring them, and utilizing simple home cultivation kits. A section on microdosing enhances the contemporary experience. Throughout the book, full-color photographs visually guide readers through the cultivation process. This practical guide offers step-by-step instructions for cultivating psilocybin-containing mushrooms indoors or outdoors. With just a clean kitchen, basic equipment, and a closet shelf or shady flowerbed, anyone can cultivate a bountiful harvest. The book also includes guidance on discreetly integrating psychedelic mushrooms into outdoor gardens. In-depth coverage of traditional cultivation ways such as using agar, grain, and the PF Tek method from the original edition is complemented by coverage of the new grow kits now readily available. Additionally, the book covers two lesser-known species: Psilocybe mexicana, revered by indigenous Mexican shamans for millennia, and Psilocybe azurescens, a newly described species thriving in the Pacific Northwest and suitable for outdoor cultivation on woodchips. Respectfully addressing the use of psilocybin-containing mushrooms in both historical and contemporary contexts, the book features contributions from ethnobotanist Kathleen Harrison. She explores the history, rituals, and mythology surrounding sacred Psilocybe mushrooms traditionally used in indigenous shamanic practices. The authors also offer insights into how these traditions can inform and benefit modern users, promoting safe, healing, and enriching journeys.