The purpose of this paper is to study the effect of debt on economic growth in Cameroon. To achieve this, we presented the concepts of the study as well as the literature on the link between them. We then proceeded to empirically verify the relationship between public debt and economic growth. A multiple linear regression model allowed us to relate public debt and economic growth. Using the ordinary least squares (OLS) method over the period 1990-2018, we find that public debt has a positive and significant influence on economic growth in the long run.