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Purinergic Receptors: Receptors and Recognition, cartea 12

Editat de G. Burnstock
en Limba Engleză Paperback – 3 noi 2011
Fifty-odd years have elapsed since the first observation of the response of visceral smooth muscle to an adenine nucleotide was reported by Drury and Szent Gyorgi (1929). It is now known that purinergic receptors mediating responses to adenosine and the adenine nucleotides (AMP, ADP and ATP) are present in all types of visceral smooth muscle. Adenine itself and other endogenous purine derivatives appear to have no direct effects, or only minimal effects, on most visceral smooth muscles. Airway smooth muscle is an exception in this regard, and responds to purine bases and non-adenine nucleosides and nucleotides. Knowledge of the distribution of purinergic receptor sites on the plasma membrane of visceral musculature has grown particularly rapidly since Burnstock and his colleagues (1970) proposed that ATP, or a related adenine derivative, is the inhibitory transmitter released from non­ cholinergic non-adrenergic nerves present in the gut. Much evidence has been presented favoring the view that ATP is the inhibitory transmitter, and evidence to the contrary has also been put forward. The hypothesis remains controversial primarily because specific blockers of the postsynaptic purinergic site, with which the hypothesis might be tested, have not been found. Nevertheless, the numerous studies designed to investigate the purinergic nerve hypothesis have generated much information concerning the nature of the purinergic receptors in visceral smooth muscle.
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Specificații

ISBN-13: 9789400958180
ISBN-10: 9400958188
Pagini: 380
Ilustrații: XII, 365 p.
Dimensiuni: 155 x 235 x 20 mm
Greutate: 0.53 kg
Ediția:Softcover reprint of the original 1st ed. 1981
Editura: SPRINGER NETHERLANDS
Colecția Springer
Seria Receptors and Recognition

Locul publicării:Dordrecht, Netherlands

Public țintă

Research

Cuprins

1 An Introduction to Purinergic Receptors.- 2 Purinergic Receptors in Visceral Smooth Muscle.- 3 Purinergic Receptors in Blood Vessels.- 4 Sites of Action and Production of Adenosine in the Heart.- 5 Brain: Intracellular and Extracellular Purinergic Receptorsystems.- 6 Presynatpric Neuromodulation Mediated by Purinergic Receptors.- 7 Blood Platelet Receptors for ADP and for Adenosine.- 8 Adenosine as a Regulator of Adenylate Cyclase.- 9 Photo-Affinity Labelling of Purinergic Receptors.