Purines in Cellular Signaling: Targets for New Drugs

Section 1: Adenosine Receptors and Effector Systems.- 1 Adenosine Agonists and Antagonists.- 2 Intracellular and Extracellular Metabolism of Adenosine and Adenine Nucleotides.- 3 Adenosine Deaminase and Adenosine Transport Systems in the CNS.- 4 Transport Systems for Adenosine in Mammalian Cell Membranes.- 5 Formation of Adenosine in the Heart from Extracellular Adenine Nucleotides.- 6 Central Nervous System Effects of Adenosine.- 7 Adenosine Receptor Sub-types in Isolated Tissues: Antagonist Studies.- 8 Molecular Probes for Adenosine Receptors.- 9 Purification of A1 Adenosine Receptor of Rat Brain Membranes by Affinity Chromatography.- 10 Characteristics of A1 Adenosine Receptors and Guanine Nucleotide Binding Proteins Co-Purified from Bovine Brain.- 11 Antagonist Radioligand Binding to Solubilized Porcine Atrial A1 Adenosine Receptors.- 12 Isolation of an Adenosine Binding Protein Which Has Properties Expected of the A1 Adenosine Receptor.- 13 Identification of the A2 Adenosine Receptor Binding Subunit by Photoaffinity Crosslinking.- 14 Human Placental Adenosine A2-Like Binding Sites Properties and Homology with Mammalian and Avian Stress Proteins.- 15 Cardiac Interstitial Fluid Adenosine in Normoxia and Hypoxia.- 16 Rationale for the Use of Adenosine in the Diagnosis and Treatment of Cardiac Arrhythmias.- 17 The Central Adenosine System as a Therapeutic Target in Stroke.- 18 Adenosine-Mediated Vasoconstriction in the Skin Microcirculation.- 19 Adenosine is an Antiinflammatory Autocoid: Adenosine Receptor Occupancy Promotes Neutrophil Chemotaxis and Inhibits Superoxide Anion Generation.- 20 Beta Adrenergic Receptor Mediated Stimulation of Adenine Nucleotide Catabolism and Purine Release in Human Adipocytes.- 21 Structure Activity Relationships for Adenosine Antagonists.- 22 Structure Activity Relationships for Adenosine Agonists.- 23 The Design of a Series of Highly A2 Selective Adenosine Agonists.- 24 Adenosine Agonists. Characterization of the N6-Subregion of the Adenosine A2 Receptor via Molecular Modeling Techniques.- 25 Physiological and Biochemical Aspects of “P”-Site-Mediated Inhibition of Adenylyl Cyclase.- 26 Adenosine Receptors Mediating Inhibition of Peripheral and Central Neurons.- 27 Adenosine Receptors as Drug Targets: Fulfilling the Promise?.- 28 Mechanisms of Adenosine Action.- 29 Functional Roles of A1 and A2 Receptors in Rat Hippocampus and Striatum.- 30 Subclassification of Neuronal Adenosine Receptors.- 31 Effects of Adenosine on Mast Cells.- 32 The Role of Adenosine on the Gastric Acid Secretory Response.- 33 Adenosine Receptors and Signaling in the Kidney.- 34 Inhibition of the Function of Guanine Nucleotide Binding Proteins by the New Positive Inotropes.- 35 Blockade of Antigen Activated Signals by Xanthine Analogs in RBL-2H3 Cells:Evidence for a Novel Adenosine Receptor.- Section 2: Adenine Nucleotide Receptors and Effector Systems.- 36 Classification and Characterization of Purinoceptors.- 37 Structure Activity Relationships for Adenine Nucleotide Receptors on Mast Cells, Human Platelets, and Smooth Muscle.- 38 Modulation of Norepinephrine Release by ATP and Adenosine.- 39 The Phospholipase C Linked P2y-Purinergic Receptor.- 40 Roles of an ADP Receptor on the Platelet Surface in Mediating Aggregation and Fibrinogen Binding.- Section 3: Phosphodiesterase Enzymes and Inhibitors.- 41 Structural and Functional Characterization of Cyclic GMP-Stimulated Phosphodiesterases and Their Role in Intracellular Signal Transduction.- 42 Phosphodiesterase Genes from Flies to Mammals.- 43 Structure and Function of the High Affinity, Rolipram and RO 2-1724 Sensitive, cAMP Phosphodiesterases.- 44 Correlation of 3H-Rolipram Binding to a Cerebral cAMP Phosphodiesterase with Antidepressant Activity.- 45 Mechanism for Dual Regulation of the Particulate cGMP-Inhibited cAMP Phosphodiesterase in Rat Adipocytes by Isoproterenol and Insulin.- 46 Expression of Calmodulin-Dependent Cyclic Nucleotide Phosphodiesterase in Developing and Adult Rat Brain.- 47 Regulation of cAMP Metabolism in PC12 Cells by Type II (cGMP-Activatable) Cyclic Nucleotide Phosphodiesterase.- 48 cGMP-Binding Phosphodiesterase: Novel Effects of cGMP Binding on the Interaction Between Functional Domains in the Enzyme.- 49 Clinical Investigations with Phosphodiesterase Inhibitors.- 50 Chemical Probes of Type IV Phosphodiesterase: Design, Synthesis, and Characterization of (3H)-2Y186126 as a Radioligand for Sites Within Cardiac Membranes.- 51 Purification of a cGMP-inhibited cAMP Phosphodiesterase from Vascular Smooth Muscle.- 52 Low KmcAMP Phosphodiesterase Isozymes and Modulation of Tone in Vascular, Airway and Gastrointestinal Smooth Muscle.- 53 Structure Activity Relationships of Xanthines as Inhibitors of Cyclic Nucleotide Phosphodiesterases and as Antagonists of Adenosine Receptors.- 54 Mechanisms of Xanthine Actions in Models of Asthma.- Section 4: Abstracts.- A Intracellular and Extracellular Metabolism of Adenosine and Adenine Nucleotides.- B Molecular Probes for Purinoceptors.- C Phosphodiesterases - Multiples Forms and Regulation.- D The Physiological Effects of Adenosine and Adenine Nucleotides.- E Structure Activity Relationships at Adenosine and ATP Receptors.- F Effector Systems for Modulation of Biological Response by Purines.- G Phosphodiesterase Inhibitors - Mechanisms and Structure Activity Relationships.- Author Index.