The reliability of medical devices is directly linked to the quality of the services provided to patients. For this reason, quality controls must be carried out regularly in every Nuclear Medicine department in accordance with international standards. Our approach began by perfecting our knowledge of the various components and acquisition modes of a gamma camera. We then carried out the various quality control tests recommended by the NEMA standard on a hybrid SPECT/CT gamma camera and a digital scintillation gamma camera, in order to assess their performance. Our study showed acceptable results, confirming that the gamma camera works well and providing better quality scintigraphic images. This guarantees the reliability and reproducibility of diagnoses.