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Radiotracers in Drug Development

Editat de Graham Lappin, Simon Temple
en Limba Engleză Paperback – 18 dec 2019
Although there are numerous books on drug metabolism, Radiotracers in Drug Development is unique in explaining how radiotracers are used to elucidate a drug’s absorption, distribution, metabolism, and excretion (ADME). Covering traditional and recent technologies and applications, the book takes a strong industrial approach, discussing the basics of scintillation counting and untangling the various data processing methods often specific to individual manufacturers. The chapters include descriptions of the latest micro-plate counters and the growing applications of accelerator mass spectrometry, positron emission tomography, gamma-scintigraphy, and radioluminography. In addition to describing how the analytical technologies work, the contributors explain how the data are interpreted and used in the drug registration process.
A unique reference and training aid essential for every drug metabolism department or drug metabolism research team, the book provides insight into the use and practice of ADME in a way that is both instructive and practical. Moving easily across the boundaries of biology, chemistry, and physics, this is the only comprehensive, interdisciplinary resource covering the how-tos of employing radiotracers in drug development. It provides detailed information on how the science is relevant to the registration process.
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Specificații

ISBN-13: 9780367453725
ISBN-10: 036745372X
Pagini: 320
Dimensiuni: 156 x 234 mm
Greutate: 0.45 kg
Ediția:1
Editura: CRC Press
Colecția CRC Press
Locul publicării:Boca Raton, United States

Public țintă

Academic and Professional Practice & Development

Cuprins

Radiotracers and Drug Registration. Radioactivity and Radiotracers. The Study of Drug Metabolism Using Radiotracers. DNA Binding, Isotope Dilution, and Other Uses of Radiotracers. Quantitative Whole-Body Autoradiography (QWBA). Scintillation Counting. Statistics in Liquid Scintillation Counting. Instrumentation for Detection of Radioactivity. Sample Preparation for Liquid Scintillation Counting. Biomedical Accelerator Mass Spectrometry. Positron Emission Tomography. Gamma Scintigraphy and SPECT.

Descriere

A unique reference and training aid that meets the essential needs of every drug metabolism department or drug metabolism research team, this book provides insight into the use and practice of ADME in a way that is both instructive and practical. Moving across biology, chemistry, and physics, this interdisciplinary resource explains how to employ r