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Real-Time Monitoring of Cancer Cell Metabolism for Drug Testing

Autor Hamed Alborzinia
en Limba Engleză Paperback – 10 iun 2015
Hamed Alborzinia uses the biosensor chip to monitor the metabolic and morphological changes in cancer cell lines in real time, particularly: (i) real-time measurements of basic cancer cell metabolism of different cancer cell lines; (ii) a detailed timeline of the metabolic response to cisplatin treatment and clear detection of the time span between start of cisplatin treatment and onset of cell death, which reflects the time required for the underlying molecular mechanisms of cell fate decision; (iii) direct functional measurement of the biological activity of a key regulatory protein of cellular metabolism following the kinetic change in respiration upon SIRT3 overexpression; and (iv) the time-resolved impact of several organometallic compounds on cell metabolism and cell morphology, including unexpected and not yet understood highly significant and specific effects on cell-cell interaction and adhesion.
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Specificații

ISBN-13: 9783658101602
ISBN-10: 3658101601
Pagini: 168
Ilustrații: XIII, 153 p. 32 illus.
Dimensiuni: 148 x 210 x 12 mm
Greutate: 0.23 kg
Ediția:2015
Editura: Springer Fachmedien Wiesbaden
Colecția Springer Spektrum
Locul publicării:Wiesbaden, Germany

Public țintă

Research

Cuprins

Drug Screening with New Perspectives.- Real-Time Monitoring of Living Cells by a Novel Online Biosensor Chip.- Anticancer Agents – Effects Measured in Real Time.- Metabolism of Cancer Cells.

Notă biografică

Hamed Alborzinia graduated in veterinary medicine from Shiraz University (Iran) in 2005 and continued in the Ph.D. program, now as post-Doc, with Prof. Dr. Stefan Wölfl at Heidelberg University (IPMB), using bioanalytical techniques in research on cancer cell metabolism.

Textul de pe ultima copertă

Hamed Alborzinia uses the biosensor chip to monitor the metabolic and morphological changes in cancer cell lines in real time, particularly: (i) real-time measurements of basic cancer cell metabolism of different cancer cell lines; (ii) a detailed timeline of the metabolic response to cisplatin treatment and clear detection of the time span between start of cisplatin treatment and onset of cell death, which reflects the time required for the underlying molecular mechanisms of cell fate decision; (iii) direct functional measurement of the biological activity of a key regulatory protein of cellular metabolism following the kinetic change in respiration upon SIRT3 overexpression; and (iv) the time-resolved impact of several organometallic compounds on cell metabolism and cell morphology, including unexpected and not yet understood highly significant and specific effects on cell-cell interaction and adhesion.
 Contents
  • Drug Screening with New Perspectives
  • Real-Time Monitoring of Living Cells by a Novel Online Biosensor Chip
  • Anticancer Agents – Effects Measured in Real Time
  • Metabolism of Cancer Cells
 Target Groups
  • Researchers and students in the fields of biotechnology and pharmacy
The Author
Hamed Alborzinia graduated in veterinary medicine from Shiraz University (Iran) in 2005 and continued in the Ph.D. program, now as post-Doc, with Prof. Dr. StefanWölfl at Heidelberg University (IPMB), using bioanalytical techniques in research on cancer cell metabolism.

Caracteristici

Publication in the field of natural sciences Includes supplementary material: sn.pub/extras