This book gathers the proceedings of the 16th International Conference on Computing and Information Technology (IC²IT 2020), held on May 14th–15th, 2020, at Dusit Thani Pattaya, Thailand. The topics covered include big data, artificial intelligence, machine learning, natural language processing, speech recognition, image and video processing, and deep learning. In turn, the topics represent major research and engineering directions for autonomous driving, language assistants, automatic translation, and answering systems. Lastly, they are responses to major economic changes around the world, which are increasingly shaped by the need for enhanced globalization and worldwide cooperation, and by emerging global problems.