Receptors in the Developing Nervous System: Volume 1 Growth factors and hormones
Editat de Zagon, McLaughlinen Limba Engleză Paperback – 5 ian 2013
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Specificații
ISBN-13: 9789401046725
ISBN-10: 9401046727
Pagini: 272
Ilustrații: XVIII, 252 p.
Greutate: 0.49 kg
Ediția:Softcover reprint of the original 1st ed. 1993
Editura: SPRINGER NETHERLANDS
Colecția Springer
Locul publicării:Dordrecht, Netherlands
ISBN-10: 9401046727
Pagini: 272
Ilustrații: XVIII, 252 p.
Greutate: 0.49 kg
Ediția:Softcover reprint of the original 1st ed. 1993
Editura: SPRINGER NETHERLANDS
Colecția Springer
Locul publicării:Dordrecht, Netherlands
Public țintă
ResearchCuprins
1 Introduction: the biology of receptors.- 1.1 Introduction.- 1.2 G protein associated receptors.- 1.3 Tyrosine kinase receptors.- 1.4 The ligand-gated ion channel receptors.- 1.5 Nuclear hormone receptors.- 1.6 Other enzyme receptors.- 1.7 Cytokine receptor superfamily.- 1.8 Conclusion.- References.- 2 Nerve growth factor receptors in the developing nervous system.- 2.1 Introduction.- 2.2 p75 neurotrophin receptor.- 2.3 The NGF receptor trk.- 2.4 NGF receptor binding.- 2.5 Conclusions.- References.- 3 Opioid growth factor receptor in the developing nervous system.- 3.1 Introduction.- 3.2 Opioid growth factor.- 3.3 The opioid growth factor receptor: zeta.- 3.4 Conclusions.- Acknowledgements.- References.- 4 Transferrin and the developing nervous system.- 4.1 Introduction.- 4.2 Iron metabolism within the CNS: what do we know?.- 4.3 Iron transport protein: molecular and cellular properties of transferrin.- 4.4 Cellular iron uptake: molecular and cellular features of the Tf receptor.- 4.5 Iron storage: ferritin.- 4.6 The Tf-R in abnormal and pathological conditions.- 4.7 Regulation of iron metabolism at the molecular level.- 4.8 Concluding remarks and future directions.- Acknowledgements.- References.- 5 Ontogenic profile of epidermal growth factor receptors in rat brain.- 5.1 Introduction.- 5.2 Methodological considerations.- 5.3 Ontogenic profile of brain EGF binding sites.- 5.4 Possible functional significance.- 5.5 Conclusion.- Acknowledgements.- References.- 6 Somatostatin receptors in the developing nervous system.- 6.1 Introduction.- 6.2 Somatostatin and the developing nervous system.- 6.3 Somatostatin receptors.- 6.4 Future directions.- References.- 7 Developmental regulation of the insulin and insulin-like growth factor receptors in the central nervous system.- 7.1 Introduction.- 7.2 Developmental regulation of insulin and IGF receptors in the CNS.- 7.3 Distribution of insulin and IGF receptors during development of the CNS.- 7.4 Characterization of insulin and IGF receptors in neural-derived tissues.- 7.5 Function of insulin and IGF receptors in the developing nervous system.- 7.6 Concluding remarks.- References.- 8 T3 Nuclear receptors in brain.- 8.1 Introduction.- 8.2 Thyroid hormone receptors.- 8.3 Thyroid hormone receptors and the erbA oncogene.- 8.4 Multiple forms of the thyroid hormone receptor.- 8.5 Ontogeny of thyroid hormones.- 8.6 Nuclear thyroid hormones: brain distribution and ontogeny.- 8.7 Effects of altered thyroid status on brain maturation.- References.- 9 Corticotropin-releasing hormone receptors and the developing nervous system.- 9.1 Introduction.- 9.2 CRH in development.- 9.3 CRH receptors in development.- 9.4 CRH receptors in aging.- 9.5 Summary and conclusions.- References.- 10 Corticosteroid receptors in the rat brain and pituitary during development and hypothalamic—pituitary—adrenal function.- 10.1 Corticosteroid receptor action.- 10.2 The HPA axis.- 10.3 Corticosteroid receptors.- 10.4 Corticosteroid receptors during early development.- 10.5 The HPA axis during early development.- 10.6 Basal HPA function during early development.- 10.7 The HPA stress response during early development.- 10.8 Glucocorticoid negative-feedback during early development.- 10.9 Conclusions: implications for neural development.- 10.10 Environmental regulation of HPA development.- 10.11 Mechanism of action of handling on glucocorticoid receptor development.- 10.12 Conclusions.- References.- 11 Estrogen receptors and the developing nervous system.- 11.1 Introduction.- 11.2 Organizational effects of steroids on the CNS.-11.3 Sites and pathways of estrogen synthesis.- 11.4 Biochemistry of the estrogen receptor.- 11.5 Estrogen receptor detection in the brain.- 11.6 Developmental changes in estrogen receptor concentrations: description and significance.- 11.7 In utero diethylstilbestrol (DES) exposure in humans.- References.- 12 Vasopressin and oxytocin receptors and the developing brain.- 12.1 Introduction.- 12.2 Vasopressin and oxytocin systems.- 12.3 Vasopressin and oxytocin receptor subtypes.- 12.4 Appearance of VP receptor.- 12.5 Appearance of OT receptor.- 12.6 Relationship with appearance of VP and OT innervation.- 12.7 Late appearance of OT receptors.- 12.8 Possible significance of transient receptor expression.- 12.9 (Early) receptor regulation.- 12.10 Possible trophic effects of VP.- 12.11 Organizational effects of VP.- 12.12 Concluding remarks.- Acknowledgements.- References.- Addendum.