Panic and plague race across the face of America, driving everyone eastward in their struggle for survival. Humans and Nightlife alike are falling prey to the Red Death, a disease that turns blood against whatever body contains it. Entire states become dead zones as governments struggle with quarantines and evacuations, not realizing that more than people are on the move. A mass migration has begun of every species that is capable of recognizing the danger. Sightings of supernatural creatures begin to surface, adding to the chaos as human fatalities climb into the millions. Included in the exodus is Maxwell Hardin, a former hunter of the Nightlife. Reborn as a vampire trapped within a body not his own, he and his blood-bound harem travel eastward on a quest to restore him to his original form and expose the masterminds behind the blood-rotting catastrophe. Time is running out as every breeze spreads the Red Death. Will this road trip be their last?