The REDE model is a conceptual framework for teaching relationship-centered communication. The REDE model applies specific skills to optimize a unique and personal connection throughout 3 different phases of Relationship: Establishment, Development, and Engagement (i.e., REDE). It is based on the premise that a genuine and authentic relationship is a vital therapeutic agent with the potential to positively influence outcomes and experiences for both the patient and provider. This advanced topic guide was designed for the self-directed learning of realtionship-centered healthcare communication using the REDE model within The Cleveland Clinic Lerner College of Medicine (CCLCM) of Case Western Reserve University. This guide includes the following topics: managing time, assessing health literacy and adherence, managing patient problems and education, use of the electronic health record, managing patient emotion, taking a sexual history, screening for violence, health behavior change, presenting an unexpected or difficult diagnosis, cultural sensitivity, establishing boundaries, interviewing when a companion is present, and transitions of care. For each topic, readers are provided with a brief summary of relevant literature and best practices followed by a behavior skills checklist. This guide can be used as an outline for an advanced communication skills course for medical students or selectively for training other health care professionals.