The Reviews in Computational Chemistry series brings together leading authorities in the field to teach the newcomer and update the expert on topics centered around molecular modeling, such as computer-assisted molecular design (CAMD), quantum chemistry, molecular mechanics and dynamics, and quantitative structure-activity relationships (QSAR). This volume, like those prior to it, features chapters by experts in various fields of computational chemistry. Topics in Volume 28 include: * Free-energy Calculations with Metadynamics * Polarizable Force Fields for Biomolecular Modeling * Modeling Protein Folding Pathways * Assessing Structural Predictions of Protein-Protein Recognition * Kinetic Monte Carlo Simulation of Electrochemical Systems * Reactivity and Dynamics at Liquid Interfaces