Sabine National Wildlife Refuge is part of the Southwest Louisiana National Wildlife Refuge Complex, which also includes Cameron Prairie National Wildlife Refuge and Lacassine National Wildlife Refuge to the east within Cameron Parish, and Shell Keys National Wildlife Refuge in Iberia Parish. The Complex also has administrative oversight responsibilities for the state-managed Rockefeller Refuge in lower Cameron Parish. Some lands within the Complex, specifically the East Cove Unit of Cameron Prairie National Wildlife Refuge, are also part of the Cameron Creole Watershed Project, a cooperative effort among local, state, and federal agencies and the private sector to restore 64,000 acres of marsh in Cameron Parish.