The evolution of implant dentistry has altered the practice of dentistry in general and replacement of missing teeth in particular. Despite their high rate of success, implants are not without problems. The initial event in the pathogenesis of most bacterial disease is by the adsorption of salivary components to the surface of the transgingival abutment or healing implant components. Oral bacteria interacts with these salivary components to adhere to the surface.Variations in pellicle constituents cause differences in bacterial adhesion and ultimately in colonization. As titanium differs in its engagement of salivary components the plaque developing on the titanium surface and its potential pathogenicity also differs.The study was aimed to identify and compare the main proteins that adsorb onto titanium surfaces in vivo, between partially dentulous and edentulous subjects using biochemical methods. They were clinically analyzed and the samples then subjected to biochemical methods to identify the individual proteins.