Sanford Hospital. A Victorianesque monstrosity with creeping ivy and the infamous Ward E, home of the soon-to-be-dead. This is where ghost hunter, Shane Ryan, ends up for his burn treatments. Courtesy of the Veterans Administration system, the ex-marine is cut off from his private doctors and thrust into the arms of a hospital with one special nurse from hell; Nurse Ruth Williamson, who is as dead as they come.

The Nurse is a whole new breed of undead. She has a cadre of helpers who are loyal to the grave. Her twisted sense of mercy is death to the dying ... and the living if they get in her way. And Shane Ryan is in her way.

Gathering his new friends and a few ghostly comrades, Shane takes up arms against the unholy regiment to fight the good fight. He can't allow the Nurse to continue her killing spree. She is not God and her legacy of death must be stopped. Although she has a few more tricks up her sleeve, Shane's mission is clear. The Nurse must die. And stay dead. Once and for all.