- Once Upon
- Once Upon Scandal
- Once and Future King
- One Fine Day
- One Last Wish
- One Lucky Woman
- One Scandalous Season
- One Thousand and One Nights
- Onedin
- Onegai Twins
- Oneworld Classics
- Oninagi
- Only Series
- Only the Ring Finger Knows
- Onslaught Cycle
- Onyx
- Op-Center
- Open City
- Open Letter Modern Classics
- Open Spaces
- Operation
- Operation Liberate Men
- Opon Ifa Readers
- Opposites Attract
- Oprah's Book Club
- Orbit
- Orchard Valley Trilogy
- Orcs
- Order of the Sanguines
- Order of the Sanguines Series
- Oregon File
- Oregon Literature
- Orell Füssli Kinderbuch
- Original Mitford Classic
- Orphan Trains Trilogy
- Orphen
- Orpheus
- Orthogonal
- Osiris
- Osiris Project
- Ostpreußisches Mosaik
- Other Press
- Other Voice in Early Modern Europe (Hardcover)
- Other Voice in Early Modern Europe (Paperback)
- Other Way Home
- Otherland
- Otherworld Novels
- Otto Penzler Books
- Oulanders
- Out in Portland
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