The present work presents a CFD simulation study for the rack storage fires and suppression means in a pharmaceutical warehouse. Simulations have been carried out for different fire locations and rack storage geometries, to predict fire growth rate and flame spread. Also, the activation time periods of in-rack and Early Suppression Fast Response(ESFR) sprinklers, fire growth control and fire suppression have been simulated. Also, the use of the foam-water sprinkler system has been considered.