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Simultaneous estimation of antiulcer and antemetic drug by using HPLC

Autor Vinod Sahu, Nilesh Jain, Surendra Jain
en Limba Engleză Paperback – 26 mai 2012

A simple, sensitive and validated HPLC method has been developed to determine esomeprazole and domperidone in tablet dosage form. The chromatographic separation was achieved on a hyperchrome C-18 column column (4.6 x 150mm, 5µ particle size) analytical column using a mixture of acetonitrile: Phosphate buffer (pH 5.0) in the ratio of 60:40 (v/v) used as the mobile phase, at a flow rate of 1.0 ml/min and detector wavelength at 290 nm. The validation of the proposed method was carried out for specificity, linearity, accuracy, precision, limit of detection, limit of quantitation and robustness. Linearity of method was found to be in concentration range 10-50 µg/ml for esomeprazole and 5-25 µg/ml for domperidone with correlation coefficient greater than 0.9999. The retention time of domperidone and esomeprazole was found to be 2.92 and 3.91 min respectively. The method can be used for simultaneous determination of esomeprazole and domperidone.

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Specificații

ISBN-13: 9783848408399
ISBN-10: 3848408392
Pagini: 84
Dimensiuni: 152 x 229 x 5 mm
Greutate: 0.14 kg
Editura: LAP LAMBERT ACADEMIC PUBLISHING AG & CO KG
Colecția LAP Lambert Academic Publishing

Notă biografică

Mr. Vinod Sahu has obtained M. Pharm degree in Pharmaceutical Chemistry. He has published various research papers in national and international journals in the field of analysis. He has also presented various research papers in national conferences.