When Maggie, Fran and Rose met in their youth, they had dreams and ambitions. Forty years later, the three friends are turning 60, each of them restless and disenchanted with their lives. Fran works in a second-hand bookshop. Her lover, one of a long line of disappointing men, is drifting away and her future is uncertain. Maggie married into a volatile family. Her beautiful, indulged twin daughters are causing havoc and her elderly mother-in-law has moved in and is taking charge. Rose has been an off-sider for her hopelessly vague but academically brilliant husband and their two sons. Time is running out to find and fulfill her own ambitions. In an attempt to recapture the sense of freedom and purpose they once possessed, they decide to retrace the steps of their 1978 backpacking trip through Europe, an odyssey that will test their friendships and redefine the third age of their lives.