Sjögren’s Syndrome: Clinical and Immunological Aspects

I. Introduction.- 1. Historical Perspective: The Early Years (1930–1960).- 2. The Patient’s Perspective.- II. Clinical Spectrum.- A. Glandular Findings.- 1. Oral Manifestations of Sjögren’s Syndrome.- 2. The Eye in Sjögren’s Syndrome.- 3. Chemistry of Saliva.- 4. Histopathology of Sjögren’s Syndrome.- B. Extraglandular Findings.- 1. Primary Sjögren’s Syndrome in the People’s Republic of China.- 2. Neuromuscular Complications of Primary Sjögren’s Syndrome.- 3. The Respiratory System in Sjögren’s Syndrome.- 4. Gastrointestinal and Hepatobiliary Features in Sjögren’s Syndrome.- 5. Renal Disease with Sjögren’s Syndrome.- 6. Inflammatory Vascular Disease in Sjögren’s Syndrome.- C. Lymphoid Malignancy.- 1. Lymphoid Malignancy and Monoclonal Proteins.- 2. Detection of Lymphoma in Sjögren’s Syndrome by Analysis of Immunoglobulin Gene Rearrangements.- 3. Lymphoproliferative Disorders in Japanese Patients with Sjögren’s Syndrome.- D. Relationship to Other Autoimmune Diseases.- 1. Relationship of Sjögren’s Syndrome to Rheumatoid Arthritis.- 2. Sjögren’s Syndrome with Systemic Lupus Erythematosus/Mixed Connective Tissue Disease.- 3. Sjögren’s Syndrome and Systemic Sclerosis (Scleroderma).- E. Diagnosis and Differential Diagnosis.- 1. Diagnosis and Differential Diagnosis of Sjögren’s Syndrome.- III. Laboratory Abnormalities.- 1. Rheumatoid Factor in Sjögren’s Syndrome.- 2. Autoantibodies in Sjögren’s Syndrome.- 3. Immunogenetics of Sjögren’s Syndrome.- 4. The Relationship Between Anti-RO(SS-A) Precipitin Antibody Positive Sjögren’s Syndrome and Anti-RO(SS-A) Precipitin Antibody Positive Lupus Erythematosus.- 5. Immunologic Abnormalities in Sjögren’s Syndrome.- 6. Animal Models of Sjögren’s Syndrome.- IV. Treatmentof Sjögren’s Syndrome.