Slow Virus Infections of the Central Nervous System: Investigational Approaches to Etiology and Pathogenesis of These Diseases

Unconventional Agents.- Scrapie: Pathogenesis in Inbred Mice: An Assessment of Host Control and Response Involving Many Strains of Agent.- Kuru, Creutzfeldt-Jakob Disease, and Transmissible Presenile Dementias.- Discussion/Chapters 1–2.- Comment/Chapters 1–2.- Sheep Progressive Pneumonia Viruses.- Discussion/Chapter 3.- Comment/Chapter 3.- Comment/Chapter 3.- Conventional Agents.- Borna, the Disease—A Summary of Our Present Knowledge.- Borna Disease: Patterns of Infection.- Discussion/Chapters 4–5.- Progressive Multifocal Leukoencephalopathy.- Discussion/Chapter 6.- Comment/Chapter 6.- Subacute Sclerosing Panencephalitis.- Comment/Chapter 7.- A Concept of Virus-Induced Demyelinating Encephalomyelitis Relative to an Animal Model.- Comment/Chapter 8.- The Biologic Role of Host-Dependent Proteolytic Cleavage of a Paramyxovirus Glycoprotein.- Discussion/Chapter 9.- Comment/Chapter 9.- Multiple Sclerosis.- Multiple Sclerosis: A Case for Viral Etiology.- In Search of the Abominable Snowman or “deine Viren, meine Viren” in Multiple Sclerosis.- Characterization of the Virus Antibody Activity of Oligoclonal IgG Produced in the Central Nervous System of Patients with Multiple Sclerosis.- Discussion/Chapters 10–12.- Demyelination in Experimental Allergic Encephalomyelitis and Multiple Sclerosis.- Genetic Aspects of Multiple Sclerosis.- Cell-Mediated Immunity in Multiple Sclerosis.- Discussion/Chapters 13–15.- Comment/Chapters 13–15.- Critique on the Investigational Approaches to Etiology and Pathogenesis.- The Virologist.- Temperature-Sensitive Viruses: Possible Role in Chronic and Inapparent Infections.- Discussion/Chapters 16–17.- The Geneticist.- Discussion/Chapter 18.- Critique: Afterthoughts of an Immunologist.- Discussion/Chapter 19.- Critique: TheEpidemiologist.- Discussion/Chapter 20.- Comment/Chapter 20.- Conclusions: Outlook on Future Research.