This Three-Volume-Set constitutes the refereed proceedings of the SecondInternational Conference on Software Engineering and Computer Systems,ICSECS 2011, held in Kuantan, Malaysia, in June 2011.The 190 revised full papers presented together with invited papers inthe three volumes were carefully reviewed and selected from numeroussubmissions. The papers are organized in topical sections on softwareengineering; network; bioinformatics and e-health; biometricstechnologies; Web engineering; neural network; parallel and distributede-learning; ontology; image processing; information and data management;engineering; software security; graphics and multimedia; databases;algorithms; signal processing; software design/testing; e- technology;ad hoc networks; social networks; software process modeling;miscellaneous topics in software engineering and computer systems.