Spirulina, cyanobacterium popularly known as one of the blue-green microalgae. Spirulina serves a limited market in "health foods", cosmetics, biochemical reagents, and colorings, etc., Worldwide, the yearly production of Spirulina now is somewhere between 20,000 and 45,000 tons of dry product. Lower costs of production by the use of a low-cost medium could be a key factor in the production of Spirulina as a feed and as a source of added-value products. Spirulina platensis was successfully cultured in Zarrouk's medium and Sea water medium with poultry dry mannure (PDM) supplementations and the biomass (dry weight), protein content, chlorophyll and phycobiliproteins were determined.