Kerry Sullivan, a transgendered male-to-female hospitalized psychiatric patient has disappeared from the unit in the middle of the night. She is unlike the nurse's typical depressed patient. She is horrified that she made the biggest mistake of her life! And Kathryn Kane, her nurse, is afraid that something dreadful has happened to her. Detective Marc Malone catches the case and works to piece together why and who would be instrumental in Kerry's disappearance. At the same time, a bizarre pattern of events start unraveling in the Windy City. A series of single, brunette women are found murdered and thrown in Chicago dumpsters. Special Agent Patrick Makenna becomes involved with Detective Sam Waters when questions arise related to a three-year old cold case he's been working on with a similar signature to these new cases. Does the abduction of Kerry have any connection to these serial murders? Meanwhile, Kathryn is taking an unusual interest in both cases, even to the point of dreaming about the murders before they occur! Kathryn is also single and brunette. Will she be next in this game of death? Will Kerry be found on time? Or is she the killer? From Chicago to San Diego to Las Vegas the race is on to find answers before madness strikes again.