This volume considers the influential revival of ancient philosophical skepticism in the 16th and early 17th centuries and investigates, from a comparative perspective, its reception in early modern English, Spanish and French drama, dedicating detailed readings to plays by Shakespeare, Calder n, Lope de Vega, Rotrou, Desfontaines, and Cervantes. While all the plays employ similar dramatic devices for putting skepticism on stage, the study explores how these dramas, however, give different answers to the challenges posed by skepticism in relation to their respective historico-cultural and ideological contexts.