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Stellate Cells in Health and Disease

Editat de Chandrashekhar Gandhi, Massimo Pinzani
en Limba Engleză Hardback – 13 apr 2015
Stellate Cells in Health and Disease is a comprehensive reference providing the most up-to-date knowledge and perspectives on the function of stellate cells affecting the liver and other organs.
The text presents comprehensive coverage of their already established role in hepatic fibrosis along with the newer emerging evidence for stellate cell participation in the liver cell (hepatocyte) survival and regeneration, hepatic immunobiology, transplant tolerance, and liver cancer.
Chapters describe both animal and human research and the relevance of findings from animal research to human pathophysiology, and also contain sections on future directions which will be of special interest to basic and clinical researchers working on liver fibrosis, hepatic biology, and pathobiology.


  • Presents coverage of the mechanisms of liver fibrosis with stellate cells as a target for therapy.
  • Shows stellate cells as a major participant in hepatic immunobiology, including transplantation immunology.
  • Key illustrations show the phenotypical changes in stellate cells in situ and tissue culture, their interactions with other cell types, signaling pathways and demonstrate the functions and roles of stellate cell in pathological processes.
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Specificații

ISBN-13: 9780128001349
ISBN-10: 0128001348
Pagini: 336
Ilustrații: 25 illustrations (25 in full color)
Dimensiuni: 191 x 235 x 33 mm
Editura: ELSEVIER SCIENCE

Public țintă

Basic and clinical researchers of gastroenteology, as well as hepatologists and practicing gastroenterologists.

Cuprins

Chapter 1. History and Early WorkChapter 2. Stellate Cell Culture ModelsChapter 3. Hepatic Fibrosis: A Global Clinical ProblemChapter 4. Stellate Cells and Hepatic FibrosisChapter 5. Cytokin Production and Signaling in Stellate CellsChapter 6. Stellate Cells, Portal Myofibroblasts and Epithelial-Mesenchymal TransitionChapter 7. Matrix Melalloproteinases and their InhibitorsChapter 8. Matrix Melalloproteinases and their InhibitorsChapter 9. Stellate Cells and Liver CancerChapter 10. Morphogens and hepatic stellate cell fate regulationChapter 11. Stellate Cells in alcoholic SteatohepatitisChapter 12. Stellate Cells as target for Reversal of Fibrosis/CirrhosisChapter 13. Interactions of Stellate Cells with other Nonparenchymal CellsChapter 14. Stellate Cells in Regulation of Hepatocyte Survival and FunctionsChapter 15. Stellate Cells in hepatic ImmunobiologyChapter 16. Stellate Cell Depletion ModelsChapter 17. Stellate Cells in Nonhepatic Organs