Stem Cells and Cancer in Hepatology: From the Essentials to Application
Editat de Yun-Wen Zhengen Limba Engleză Paperback – 23 mai 2018
- Addresses both the basic and clinical perspectives of the topic, including sections on normal and cancer stem cells of the liver
- Provides coverage of the molecular mechanisms of liver development, the proliferation of hepatic progenitor cells during development, epithelial cell plasticity, generation of hepatocytes by transdifferentiation, liver tissue engineering, and more
- Presents a study of hepatic stem cells that will help readers understand critical events during development, stem cell differentiation towards functional liver cell fate, and tumor initiation
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Specificații
ISBN-13: 9780128123010
ISBN-10: 012812301X
Pagini: 382
Dimensiuni: 152 x 229 x 16 mm
Editura: ELSEVIER SCIENCE
ISBN-10: 012812301X
Pagini: 382
Dimensiuni: 152 x 229 x 16 mm
Editura: ELSEVIER SCIENCE
Public țintă
Basic scientists (graduates, postgraduates and research scholars) and clinicians in the field of stem cells, cancer stem cells, hepatology and oncologyCuprins
1. Molecular mechanisms of liver development: lessons from knockout mice and mutant fish 2. The regulation of proliferation and maturation of hepatic progenitor cells during liver development 3. Plasticity of liver epithelial cells in healthy and injured livers 4. Stem cells in the liver and the organ size control 5. Generation of liver progenitor cells by chemical reprogramming 6. Generation of hepatocytes by transdifferentiation 7. Generation of liver organoids and the potential application 8. Reconstitution of liver tissue with engineered multicellular spheroids 9. Role of platelet, blood stem cell and thrombopoietin in liver regeneration and liver diseases 10. Dynamic tissue remodeling in chronic liver diseases: abnormal proliferation and differentiation of hepatocytes and bile ducts/ductules 11. Stem cells in the hepato-biliary system and in the development of cancer: the points of view from a surgeon 12. Stem cells in the chronically injured livers and the interaction with their environment 13. Stem cells in the liver cancers and the controversial 13. Characteristics and clinical significance of liver cancer stem cells 14. Clinical application of stem cells in liver diseases: from bench to bedside