This report discusses opportunities for safe and environment-friendly agriculture products in the Greater Mekong Subregion and highlights the Siem Reap Action Plan, 20182022. As the Greater Mekong Subregion (GMS) has made considerable progress in food security, addressing health, safety, and environmental concerns is also essential. The strategy and action plan will strengthen the commitment to food security, increase market access for small producers, and ensure inclusive food safety for the GMS. It aims at achieving the GMS vision of being a leading global supplier of safe and environment-friendly agriculture products through four pillars: policies, infrastructure, knowledge, and marketing.