Members of the Center for Technology and National Security Policy (CTNSP) at the National Defense University in Washington, DC, examined various management practices and implications of laboratory administration for the U.S. Department of Homeland Security (DHS). This paper summarizes the second phase of a research and analysis project that stemmed from the initial work which provided DHS Science and Technology (S&T) leadership with examples of practical approaches to risk-informed decisionmaking and metrics for program and project selection.1 The second phase was undertaken to provide additional relevant information to DHS as it seeks to strengthen its laboratory programs.