Structure, Function, and Regulation of Molecules Involved in Leukocyte Adhesion de Peter E. Lipsky

Structure, Function, and Regulation of Molecules Involved in Leukocyte Adhesion

Peter E. Lipsky

Robert Rothlein

Takashi K. Kishimoto

Ronald B. Faanes

C. Wayne Smith

Leukocyte adhesion molecules have been the subject of intense basic and preclinical research. Results from clinical trials obtained sofar with antibodies directed towards these surface proteins offer promise for the prevention of graft rejection and effective treatment of acute and chronic inflammatory disease. This volume presents a comprehensive review of contemporary research on the structure, function and regulation of leukocyte adhesion molecules and their ligands, from the molecular to the clinical level. The blend of basic science and clinical applications presented in Structure, Function and Regulation of Molecules Involved in Leukocyte Adhesion provides clear evidence of the biological importance of cell-cell interactions and the many potential clinical dividends afforded by understanding the molecular basis of cell adhesion. It will appeal to a broad range of readers in immunology and cell biology.

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1: Structure and Function of the Integrins.- 1. Leukocyte Integrin Activation.- 2. Activation of LFA-1: Role of Cations.- 3. An Antibody that Promotes Adhesion Events Mediated by Both LFA-1 and CR3.- 4. Function of a Soluble Human ?2 Integrin CD11b/CD18.- 5. Mac-1 (CD11b/CD18) and Adherence-Dependent Neutrophil Locomotion.- 6. Functional Comparison of the Integrins ?4?1 (VLA-4) and ?4?7.- 7. Functional Mapping and Regulation of VLA-4 Adhesion Activities.- 8. Signal Transduction Through a Novel Phagocyte Integrin.- 9. Interactions of the Plasmodium falciparum-Infected Erythrocyte With ICAM-1.- 2: Structure and Function of the Selectins.- 10. The Selectins.- 11. Leukocyte Interactions Mediated by P-Selectin.- 12. PMN Extravasation in Acute Inflammation: A Role for Selectin Interaction in Initial PMN-Endothelial Cell Recognition.- 13. Interaction of LAM-1 With an Inducible Ligand Supports Leukocyte Adhesion to Endothelium.- 14. The Contribution of L-Selectin to Leukocyte Trafficking In Vivo.- 15. L-Selectin as a Mediator of Leukocyte Binding to Myelinated Tracts of the Central Nervous System: Possible Pathophysiologic Significance.- 16. Selectin-Dependent Monocyte Adhesion in Frozen Sections of Rheumatoid Synovitis.- 3: Cell Biology of Adhesion Molecules.- 17. Fc Receptor Function and Cytoplasmic Domain Heterogeneity.- 18. Regulation of Antigen-Independent Adhesion of CD4 T Cells.- 19. The Adhesion and Transendothelial Migration of Human T Lymphocytes.- 20. Changes in Topography of Cell Adhesion Molecules During Lymphocyte Migration Across Endothelium.- 21. Cytokines and the Control of Endothelial Cell Adhesiveness for Leukocytes in Inflammation.- 22. Co-stimulation of T-Lymphocyte Activation by Adhesion Molecules.- 4: In Vivo Models.- 23. The Role of CD11a/CD18–CD54 Interactions in the Evolution of Animal Models of Tissue Injury.- 24. Mechanisms and Consequences of Leukocyte Adhesion.- 25. The Role of Cellular Adhesion Molecules in Acute and Chronic Airway Inflammation.- 26. Adhesion Molecules in the Shwartzman Response.- 27. Clinical and Immunological Features Associated with Bovine Leukocyte Adhesion Deficiency.- 28. The Role of Leukocyte Adhesion Molecules During Ischemia and Reperfusion.- 5: Clinical.- 29. Abnormalities of LECAM-1- and MAC-1-Dependent Neutrophil-Endothelial Cell Adhesion in the Developing Host.- 30. Expression of ICAM-1 in Human Liver.- 31. Detection and Characterization of Circulating ICAM-1.- 32. Phase I Clinical Trial of Anti-ICAM-1 (CD54) Monoclonal Antibody Immunosuppression in Renal Allograft Recipients.- 33. Adhesion Molecules in Human Renal Allograft Rejection: Immunohistochemical Analysis of ICAM-1, ICAM-2, ICAM-3, VCAM-1, and ELAM-1.