Cantitate/Preț
Produs

Structure-Related Anti-Inflammatory Mechanisms of Probiotic Bacteria


en Limba Engleză Paperback
During the last years it became more and more obvious that the intestinal microbiota is pivotal for the intestinal and overall health of human beings. Consequently, the modulation of the intestinal microbiota in order to maintain or increase health gained a lot of attention. In this context, clinical studies revealed that the uptake of specific probiotic strains can indeed be effective in the prevention and reduction of a major disease of civilisation, inflammatory bowel disease. However, a broad, safe and effective use of probiotics in the clinic is hampered by the lack of mechanistic understanding. Specifically, there is almost nothing known regarding the molecular mechanisms that are induced by probiotics in the host or the bacterial structures that are responsible for the observed protective effect. The present work therefore aimed to unravel these questions with regard to a clinically relevant probiotic mixture, VSL#3. In summary, it was found that VSL#3 mediates selective post-translational degradation of a major proinflammatory chemokine, IP-10. The bacterial protease lactocepin, expressed by Lactocbacillus casei VSL#3, was identified to be the active anti-inflammatory probiotic structure. These findings enable a more structure-related evaluation of new probiotics as well as the future development of anti-inflammatory drugs based on probiotic lactocepin.
Citește tot Restrânge

Preț: 36977 lei

Preț vechi: 38922 lei
-5% Nou

Puncte Express: 555

Preț estimativ în valută:
7080 7372$ 5874£

Indisponibil temporar

Doresc să fiu notificat când acest titlu va fi disponibil:

Preluare comenzi: 021 569.72.76

Specificații

ISBN-13: 9783832525811
ISBN-10: 3832525815
Pagini: 110
Editura: Logos Verlag Berlin