0Design, synthesis and biological evaluation of sulphonyl urea and guanidine derivatives as hypoglycemic agents Design and synthesis of sulphonyl urea and guanidine derivatives as hypoglycemic agents has been performed which is based on the indirect molecular modeling approach by checking the superimposibility of the designed molecule and reported compound N-(6-substituted-1,3-benzothiazol-2-yl)-benzene-sulfonamides. Synthesized compounds were characterized by TLC, UV spectra, IR spectra, Mass spectra & 1H NMR. All the synthesized compounds were subjected to OGTT to gain preliminary information regarding the anti hyperglycemic effect in normal Albino Wister rats which were chosen for the study. Glibenclamide was chosen as the standard. Comparisiton of data was performed by one way ANOVA followed by post test and Dunnett's multiple comparison tests. The work of Mr. Ishan I. Panchal on this project has been carried out under the joint supervision of Dr. Bibhuranjan Panigrahi, Dr. Kamal Modh and Dr. C.N. Patel during M.Pharm. project in 2009-2011 and has been published in Der Pharma Chemica;3(2):383-391,2011(ISSN:0975-413X)