Synthesis has been the back bone of synthetic organic chemistry since the time Friedrich Wohler accidentally synthesized urea as an organic material from an inorganic material - ammonium cyanate in 1828. This proved that nonliving substances can be used to reproduce substances made by living things. The scientific research of organic synthesis is continuously enriched by the development of synthetic methodology. Domino reaction is a synthesis of complex molecules in which at least three functional groups join through covalent bonds by combining three or more components in a single step. Domino reaction always plays a major role in synthetic organic chemistry, and has emerged as a potentially effective tool for the generation of diverse set of compounds. These types of reactions have attracted greater attention which can be adopted in drug discovery as well as in total synthesis. Synthesizing various target molecules using domino reaction has posed the most challenging objectives in the recent decade; mostly nitrogen containing heterocycles such as lactams, 1, 3] oxazines etc., possessing biological and industrial application.