Antibacterial resistance is an increasing treat in infectious disease treatment requiring the discovery of new compounds. Dehydrozingerone, a curcumin degradant has attracted investigations because of its pharmacological activities. In this study, 22 compounds were synthesized and screened on 6 bacteria: Staphylococcus aureus, Meticilin Resistant Staphylococcus aureus, Escherisia coli, Pseudomonas aeruginosa, Klebsiala pneumonia, Salmonela Tiphymurium. All compounds tested displayed activity on at last two bacteria.