The book describes the synthesis of schiff bases possessing pyrazole derivatives. The synthesized entities were characterized for their formation using spectral techniques viz. IR and NMR. The derivatives were tested for their antimicrobial results and were compared with 5 different standard drugs available in the market. The compounds, thus synthesized were found to be good antimicrobial agents. The derivatives synthesized can be further optimized to generate lead for the better future of the society.