The book contains synthesis of three different azomethines (HL1, HL2, HL3) and 13 different organotin(IV) azomethine derivatives of HL1, HL2. These newly compounds were characterized successfully by elemental analysis, FT-IR, 1H, 13C and 119Sn NMR spectroscopy. The ligands and their complexes were screened for their biological activities such as interaction with DNA, enzymatic, antimicrobial, cytotoxic and antioxidant activities.