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Synthesis of Aziridines and Oxaziridines from Imines

Autor Navjeet Kaur
en Limba Engleză Paperback – 16 ian 2024
Synthesis of Aziridines and Oxaziridines from Imines describes both new and old methods for the synthesis of aziridines from imines and covers an important and rapidly growing branch of heterocyclic chemistry. Readers will have access to different methods and information allowing them to evaluate which method is most suitable for particular cases. Several important advances in this area have been witnessed in recent years and discovering efficient novel methods for the synthesis of aziridines has been very active field of research. Its powerful synthetic utility has been described by an overpowering amount of documentation on the approaches for the formation of aziridine. The smallest possible saturated azaheterocycle, aziridine, is well-known to organic chemists for its tremendous potential in pharmaceutical chemistry and organic synthesis. The general biological importance of aziridines is proven by the fact that they found several uses as subunits in pharmacologically active compounds such as antitumor agents, enzyme inhibitors, and antibiotics. Although aziridines are highly reactive, this framework occurs in many synthetic compounds and the natural products of biological interest also contain aziridine skeleton in their structures.


  • Focuses on the biological importance of different heterocycles
  • Describes traditional and innovative methods for the synthesis of aziridines from imines
  • Includes comparison amongst different methods, reagents, reaction conditions in tabulated forms, advantages, disadvantages, and critical analysis of different methodologies with respect to their comparison with green technique
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Specificații

ISBN-13: 9780443220593
ISBN-10: 044322059X
Pagini: 352
Dimensiuni: 191 x 235 x 20 mm
Greutate: 0.74 kg
Editura: ELSEVIER SCIENCE

Cuprins

1. Aziridine synthesis from imines-I 2. Aziridine synthesis from imines-II 3. Aziridine synthesis by condensation of phenylimines with ethyl diazoacetate 4. Aziridine synthesis by metal-catalyzed condensation of phenylimines with ethyl diazoacetate 5. Aziridine synthesis by addition of biphenyl imines to ethyl diazoacetate 6. Aziridine synthesis by metal-catalyzed addition of biphenyl imines to ethyl diazoacetate 7. Aziridine synthesis by condensation of imines with diazo compounds 8. Aziridine synthesis by condensation of imines with diazomethane 9. Aziridine synthesis by ring-closure of haloimines 10. Aziridine synthesis by ring-closure of imines and halo compounds 11. Aziridine synthesis by alkene-imine and alkyne-imine reactions 12. Oxaziridine synthesis from imines 13. Oxaziridine synthesis from imines using m-CPBA