This book reported the literature survey of the chemistry of enaminonitriles. The activity of enaminonitriles and their synthetic importance were investigated. Syntheses, reactions and the applications of enaminonitriles and good introduction about the literature survey of the inhibition of C-steel surface and inhibition in acid media were also investigated. Furthermore, the obtained results were discussed, 43 novel compounds were synthesized, the synthetic mechanisms were investigated and compounds were established by elemental analyses and spectral data. Antipyrines incorporating different heterocycles such as pyrazole, pyridine, pyrimidine, diazepine, and oxazocine were synthesized. This book evaluated the inhibition efficiency of three enaminonitriles in acid medium by three different modern techniques. The investigated compounds exhibited good antioxidant, anticancer and hemolysis activities. Finally, the experimental methods were included.