Systems Biological Approaches in Infectious Diseases: Progress in Drug Research, cartea 64
Editat de Helena I. Boshoff, Clifton E. Barryen Limba Engleză Hardback – 20 noi 2006
This book brings together the various fields of functional genomics and systems biology that provide information on metabolic function with a special emphasis on the identification of drug targets. It includes practical examples from the various "omic" sciences as well as theoretical examples of how integrated knowledge of these sciences can be applied to drug discovery. It is of interest to researchers in the pharmaceutical drug discovery environment, as well as those in the academic field with an interest in the functional application of the "omic" sciences.
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Specificații
ISBN-13: 9783764375669
ISBN-10: 3764375663
Pagini: 350
Ilustrații: IX, 350 p.
Dimensiuni: 170 x 244 x 24 mm
Greutate: 0.93 kg
Ediția:2007
Editura: Birkhäuser Basel
Colecția Birkhäuser
Seria Progress in Drug Research
Locul publicării:Basel, Switzerland
ISBN-10: 3764375663
Pagini: 350
Ilustrații: IX, 350 p.
Dimensiuni: 170 x 244 x 24 mm
Greutate: 0.93 kg
Ediția:2007
Editura: Birkhäuser Basel
Colecția Birkhäuser
Seria Progress in Drug Research
Locul publicării:Basel, Switzerland
Public țintă
ResearchCuprins
Systems biology and its impact on anti-infective drug development.- Applications of transcriptional profiling in antibiotics discovery and development.- Chemical genetics: An evolving toolbox for target identification and lead optimization.- Proteomic profiling of cellular stresses in Bacillus subtilis reveals cellular networks and assists in elucidating antibiotic mechanisms of action.- Elucidating the mode-of-action of compounds from metabolite profiling studies.- A subsystems-based approach to the identification of drug targets in bacterial pathogens.- Metabolic control analysis to identify optimal drug targets.- The protein network as a tool for finding novel drug targets.- Toxicogenomics applied to predictive and exploratory toxicology for the safety assessment of new chemical entities: a long road with deep potholes.- Biological robustness in complex host-pathogen systems.- Toward whole cell modeling and simulation: Comprehensive functional genomics through the constraint-based approach.- Genomics of host-pathogen interactions.
Textul de pe ultima copertă
Systems biology is an emerging discipline that studies the underlying network structure and the dynamics of metabolism, cells or whole organisms. It aims to investigate all interacting components simultaneously and requires data from high throughput techniques. These data from the "omic" sciences are computed and used to build in silico models of biological systems that ultimately will prove to be an invaluable tool in drug development.
This book brings together the various fields of functional genomics and systems biology that provide information on metabolic function with a special emphasis on the identification of drug targets. It includes practical examples from the various "omic" sciences as well as theoretical examples of how integrated knowledge of these sciences can be applied to drug discovery. It is of interest to researchers in the pharmaceutical drug discovery environment, as well as those in the academic field with an interest in the functional application of the "omic" sciences.
This book brings together the various fields of functional genomics and systems biology that provide information on metabolic function with a special emphasis on the identification of drug targets. It includes practical examples from the various "omic" sciences as well as theoretical examples of how integrated knowledge of these sciences can be applied to drug discovery. It is of interest to researchers in the pharmaceutical drug discovery environment, as well as those in the academic field with an interest in the functional application of the "omic" sciences.
Caracteristici
Gives an overview of computation and modelling of "omics" data Special emphasis on identification of novel drug targets Includes supplementary material: sn.pub/extras