Systems Biology and In-Depth Applications for Unlocking Diseases: Principles, Tools, and Application to Disease
Editat de Babak Sokoutien Limba Engleză Paperback – dec 2024
- Provides detailed and comprehensive coverage of the field of systems biology
- Delivers instruction on how to interrogate biological data, with the purpose of obtaining insight about disease diagnosis, prognosis, and treatment
- Makes effective steps towards personalized medicine in the treatment of disease
- Explains effective disease treatment strategies at early diagnosis stages
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Specificații
ISBN-13: 9780443223266
ISBN-10: 0443223262
Pagini: 300
Dimensiuni: 216 x 276 mm
Editura: ELSEVIER SCIENCE
ISBN-10: 0443223262
Pagini: 300
Dimensiuni: 216 x 276 mm
Editura: ELSEVIER SCIENCE
Cuprins
Part 1. Introduction 1.1 Systems biology at a glance 1.2. A history on systems biology evolution 1.3. Brief information on cellular biology and signaling pathways 1.4. Systems biology: where are we? 1.5. Filling the gaps between systems biology and cell biology 1.6 Concluding remarks 1.7 Mathematical concepts 1.5. Kinetic and dynamics of biological systems Part 2. Tools and Resources 2.1. Biological data sources 2.1.1. Microarray 2.1.2. Next generation sequencing (NGS) 2.1.3. Comparative genomic hybridization (CGH) 2.1.4. Single nucleotide polymorphisms (SNP) 2.2. High throughput data 2.1.2. Databases 2.3. Programming, tools and software Part 3. Systems biology in action – to understand diseases 3.1 Big data analysis techniques 3.2 Reconstruction of genome and proteomic scale network structures and functions 3.3 Validation strategies 3.3.1 Mathematical model development 3.3.2 Biological gene expression models 3.3.3 Experimental techniques 3.4 Applications of systems biology extensions in diseases 3.4.1 Systems immunology 3.4.2 Systems pharmacology 3.4.3 Systems virology 3.4.4 Systems vaccinology 3.4.5 Systems neuroscience 3.4.6 Systems medicine 3.4.7 Future directions on systems biology