Targeted Drug Delivery de Y Bachhav

Targeted Drug Delivery: Methods & Principles in Medicinal Chemistry

Y Bachhav

Highlights the critical role of targeted drug delivery for unmet medical needs, by describing a wide range of different approaches for targeting small molecule as well as peptide and macromolecular drugs.

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Notă biografică

Yogeshwar Bachhav is a pharmacist by training and holds a PhD in drug delivery systems from ICT, Mumbai (India). He has worked as research scientist for several years on a collaborative project between Pantec Biosolutions and Geneva University (Switzerland), and as formulation manager at Debiopharm Group, Lausanne (Switzerland). For the last 5 years he has been working as Associate Director at AiCuris Anti-infective Cures GmbH, Germany and has been responsible for pharmaceutical development. In total, he has around 14 years of experience in the preformulation and formulation development of small molecules and/or peptides for oral, dermal and parenteral application. He has more than 16 international publications, 6 European patents and over 30 conference proceedings to his credit. He has recently edited a book for Wiley-VCH: Innovative Dosage Forms: Design and Development at Early Stage.

Cuprins

Basics of Targeted Drug Delivery Addressing Unmet Medical Needs using Targeted Drug Delivery Systems: Emphasis on Nanomedicine-Based Applications Nanocarriers Based Targeted Drug Delivery Systems: Small and Macromolecules Liposomes as Targeted Drug Delivery Systems Antibody-Drug Conjugates: Development and Applications Gene-Directed Enzyme Prodrug Therapy (GDEPT) as a Suicide Gene Therapy Modality for Cancer Treatment Targeted Prodrugs in Oral Drug Delivery Exosomes for Drug Delivery Applications in Cancer and Cardiac Indications Delivery of Nucleic Acids such as siRNA and mRNA using Complex Formulations Application of PROTAC Technology in Drug Development Metal Complexes as the Means or the End of Targeted Delivery for Unmet Needs Formulation of Peptides for Targeted Delivery Antibody-Based Targeted T Cell Therapies Devices for Active Targeted Delivery: A Way to Control the Rate and Extent of Drug Administration Drug Delivery to the Brain: Targeting Technologies to Delivery Therapeutics to Brain Lesions