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Targeted Protein Degradation Technologies

Editat de Jiangjiang Qin, Xin Luan, Weidong Zhang
en Limba Engleză Paperback – 31 iul 2025
Targeted Protein Degradation Technologies provides a thorough overview of targeted protein degradation from the latest developments in the field to potential therapeutic applications. The book begins with an introduction to the mechanisms of protein degradation followed by a section covering both protease-mediate degradation and lysosome-mediate degradation. A range of cutting-edge technologies are covered, including PROTAC, AbTAC, molecular glues, hydrophobic tagging, LYTAC, GlueTAC and AUTAC. Degraders of specific proteins are then investigated, including signal transduction receptors, membrane proteins, and transcription factor degraders.

The book closes with a section on the clinical applications of targeted protein degradation and a look at future perspectives. It is a useful resource to those in the fields of molecular biology, cell biology, and related areas working with protein degradation and the development of therapeutic technologies in this arena.


  • Offers a foundational introduction to the mechanisms of protein degradation
  • Features a range of targeted protein degradation technologies and covers the latest advances in each area
  • Explores the clinical potential of protein degraders in drug discovery
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Specificații

ISBN-13: 9780443218163
ISBN-10: 0443218161
Pagini: 320
Dimensiuni: 191 x 235 mm
Editura: ELSEVIER SCIENCE

Cuprins

Part 1: Introduction
1. Mechanisms of protein degradation
2. Overview of targeted protein degradation

Part 2: Summary of targeted protein degradation
3. Protease-mediate degradation
4. PROTAC
5. AbTAC
6. Molecular glues
7. Hydrophobic tagging technology
8. Lysosome-mediate degradation
9. LYTACs
10. Bispecific Apt amer Chimera (BIAC)
11. GlueTAC
12. AUTACs
13. ATTECs
14. AUTOTAC

Part 3: Degradation of Proteinsof Interest
15. Degraders of signal transduction receptors
16. Degraders of membrane-associated proteins
17. Degraders of cell cycle- and anti-apoptosis-related proteins
18. Degraders of proteins in epigenetic regulation
19. Degraders of proteins involved in transcription nuclear hormone receptors
20. Transcription factor degraders

Part 4: Clinical applications of targeted protein degradation
21. Clinical development of protein degraders