Targeted Protein Degradation Technologies
Editat de Jiangjiang Qin, Xin Luan, Weidong Zhangen Limba Engleză Paperback – 31 iul 2025
The book closes with a section on the clinical applications of targeted protein degradation and a look at future perspectives. It is a useful resource to those in the fields of molecular biology, cell biology, and related areas working with protein degradation and the development of therapeutic technologies in this arena.
- Offers a foundational introduction to the mechanisms of protein degradation
- Features a range of targeted protein degradation technologies and covers the latest advances in each area
- Explores the clinical potential of protein degraders in drug discovery
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Specificații
ISBN-13: 9780443218163
ISBN-10: 0443218161
Pagini: 320
Dimensiuni: 191 x 235 mm
Editura: ELSEVIER SCIENCE
ISBN-10: 0443218161
Pagini: 320
Dimensiuni: 191 x 235 mm
Editura: ELSEVIER SCIENCE
Cuprins
Part 1: Introduction
1. Mechanisms of protein degradation
2. Overview of targeted protein degradation
Part 2: Summary of targeted protein degradation
3. Protease-mediate degradation
4. PROTAC
5. AbTAC
6. Molecular glues
7. Hydrophobic tagging technology
8. Lysosome-mediate degradation
9. LYTACs
10. Bispecific Apt amer Chimera (BIAC)
11. GlueTAC
12. AUTACs
13. ATTECs
14. AUTOTAC
Part 3: Degradation of Proteinsof Interest
15. Degraders of signal transduction receptors
16. Degraders of membrane-associated proteins
17. Degraders of cell cycle- and anti-apoptosis-related proteins
18. Degraders of proteins in epigenetic regulation
19. Degraders of proteins involved in transcription nuclear hormone receptors
20. Transcription factor degraders
Part 4: Clinical applications of targeted protein degradation
21. Clinical development of protein degraders
1. Mechanisms of protein degradation
2. Overview of targeted protein degradation
Part 2: Summary of targeted protein degradation
3. Protease-mediate degradation
4. PROTAC
5. AbTAC
6. Molecular glues
7. Hydrophobic tagging technology
8. Lysosome-mediate degradation
9. LYTACs
10. Bispecific Apt amer Chimera (BIAC)
11. GlueTAC
12. AUTACs
13. ATTECs
14. AUTOTAC
Part 3: Degradation of Proteinsof Interest
15. Degraders of signal transduction receptors
16. Degraders of membrane-associated proteins
17. Degraders of cell cycle- and anti-apoptosis-related proteins
18. Degraders of proteins in epigenetic regulation
19. Degraders of proteins involved in transcription nuclear hormone receptors
20. Transcription factor degraders
Part 4: Clinical applications of targeted protein degradation
21. Clinical development of protein degraders